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夏宁邵，教授，博士生导师
厦门大学生物系教授（2002），博士生导师（2003）。
1990年起从事医学病毒相关基因工程重组抗原、疫苗、诊断试剂的研究与开发及相应病毒分子生物学、免疫学基础研究。完成或正在承担的各级各类研究项目共计20余项，其中包括国家“863”计划项目3项、“九五”攻关项目2项、“十五”攻关项目3项以及省、市级重大科技项目6项。获得国家新药证书5项，申请国际国内发明专利15项。
作为主要负责人，2003年组织创建“福建省医学分子病毒学研究中心”，2005年组织创建“国家传染病诊断试剂与疫苗工程技术研究中心”，担任中心主任。1992年主持获得1项湖南省科技进步二等奖，1993年获国务院特殊津贴，1998年再次主持获得1项湖南省科技进步二等奖。2001年主持获得1项国家科技进步二等奖，2001年获厦门市首届科技重大贡献奖，2001年获科技部863十五周年先进个人称号，2002年列入教育部跨世纪优秀人才培养计划。2004年列入国家新世纪百千万人才计划，2004年获福建省五一劳动奖章和福建省十大杰出青年，2005年获选全国劳动模范。
电话：（0592）2184110
传真：（0592）2181258
电子信箱：nsxia@xmu.edu.cn
研究兴趣：
医学病毒相关基因工程重组抗原、疫苗、诊断试剂的研究与开发及相应病毒分子生物学、免疫学基础研究。
Xia ningshao
Professor in Biochemistry and Molecular Biology, Ph.D. Supervisor
Professor Xia has successfully completed many great projects which include “National 863 High Tech Foundation”, “National Natural Science Foundation of China”, “National Key Technologies Research and Development Program of China” and other national or provincial scientific research projects. He has obtained 4 national new medicine certificates and 9 national invention patents. Professor Xia was authorized to entrance the Crossing Century Elitist Culture Plan sponsored by the national Ministry of Education in 2002. He founded “The Research Center for Medical Molecular Virology of Fujian Province” in 2003. Main awards: National Scientific and Technological Progress Prize (Second Class, 2002); Chinese university Scientific and Technological Progress Prize (first Class, 2001); Scientific and Technological great contribution Prize in Xiamen (2001), Scientific and Technological Progress Prize in Hunan province (Second Class, 1998 and 1992) .
Tel：（0592）2184110
Fax：（0592）2181258
E-mail：nsxia@xmu.edu.cn
Research Interests：Research and development of recombinant antigen, vaccine and diagnostic kits related to medical viruses and fundamental research on molecular biology and immunology of these viruses.
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Xia Ningshao
Professor in Biochemistry and Molecular Biology
主要研究成果：
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在国际上首先鉴定出了2个戊型肝炎病毒中和表位，并首先利用大肠杆菌表达出了戊型肝炎类病毒颗粒，相关成果已申请3项国际发明专利，申报的国家一类新药“重组戊型肝炎疫苗”已完成I、II期临床试验。
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研制的艾滋病毒重组抗原及第三代诊断试剂盒，与国际上目前最好的试剂处于同等水平。该项产品已连续两年占据全国艾滋病毒检测试剂20%的市场，总销量全国第一。2002年该试剂盒被科技部等6部委列入“国家重点新产品”，2003年该项目被国家计委选为“产业化示范工程”项目。
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与香港大学、汕头大学合作，于2004年11月研制出了世界上首个高致病性禽流感特异性快速诊断试剂盒。该项目于2005年获国家科技攻关计划，高致病性禽流感防治科技专项资助。
近年发表主要论文：
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RC Li, SX Ge, YP Li, YJ Zheng Y Nong, QS Guo, J Zhang, MH Ng, NS Xia*. Seroprevalence of hepatitis E Virus infection, rural southern People’s Republic of China, Emerging Infectious Diseases, 2006,12(11):1682-1688.
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YJ Zheng, SX Ge, J Zhang, QS Guo, MH Ng, FD Wang, NS Xia*, QW Jiang. Swine are a principal source of hepatitis E virus infection in eastern China. Journal of Infectious Diseases, 2006,193:1643-1649.
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Shao-Wei Li, Jun Zhang, Zhi-Qiang He, Ying Gu, Ru-Shi Liu, Jian Lin, Yi-Xin Chen, Mun-Hon Ng, Ning-Shao Xia*. Mutational analysis of essential interactions involved in the assembly of Hepatitis E Virus capsid. J Biol Chem 2005,280(5):3400-3406
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Zhang J, Gu Y, Ge SX, Li SW, HE ZQ, Huang GY, Zhuang H, Ng MH, Xia NS*. Analysis of hepatitis E virus neutralization sites using monoclonal antibodies directed against a virus capsid protein. Vaccine 2005,23(22): 2881-2892
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Li SW, Zhang J, Li YM, Ou SH, Huang GY, He ZQ, Ge SX, Xian YL, Pang SQ, Ng MH, Xia NS*. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and efficacy for primates. Vaccine 2005, 23(22): 2893-2901
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Min Chen, Tong Cheng, Chen-Yu Xu, Ting Wu, Shan-Hai Ou, Tao Zhang, Jun Zhang, Ning-Shao Xia*. Hydrophobicity of reactive site loop of SCCA1 affects its binding to hepatitis B virus. World J Gastroenterol 2005; 11(19): 2864-2868
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Liu Ru-Shi, Yang, Kun-Yu, Lin Jian, Lin Yi-Wei, Zhang Zhi-Hong, Zhang Jun, Xia Ning-Shao*. High-yield expression of recombinant SARS coronavirus nucleocapsid protein in methylotrophic yeast Pichia pastoris. World J Gastroenterol, 2004, 10(24): 3602-3607
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Gu Ying, Zhang Jun, Wang Ying-Bing, Li Shao-Wei, Yang Hai-Jie, Luo Wen-Xin, Xia Ning-Shao*. Selection of a peptide mimicking neutralization epitope of hepatitis E virus with phage peptide display technology. World J Gastroenterol 2004;10(11):1583-1588
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Cheng Tong, Xu Chen-Yu, Wang Ying-Bin, Chen Min, Wu Ting, Zhang Jun, Xia Ning-Shao*. A rapid and efficient method to express target genes in mammalian cells by baculovirus. World J Gastroenterol 2004;10(11):1612-1618
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Xia Ning-Shao*，Zhang Jun，Zheng Ying-Jie，Ge Sheng-Xiang，Ye Xiang-Zhong，Ou Shan-Hai. Transfusion of Plasma from a Blood Donor Induced Hepatitis E in Rhesus Monkey. Vox Sang, 2004, 86(1):45-47
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Ma Ying, Lin Shun-Quan, Gao Yi, Li Mei, Luo Wen-Xin, Zhang Jun, Xia Ning-shao*. Expression of ORF2 partial gene of hepatitis E virus in tomatoes and immunoactivity of expression products. World J Gastroenterol, 2003, 9(10): 2211-2215.
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Zhang J, Ge SX, Huang GY, Li SW, He ZQ, Wang YB, Zheng YJ, Gu Y, Ng MH, Xia NS*. Evaluation of antibody based and nucleic acid based assays for diagnosis of Hepatitis E Virus infection in a rhesus monkey model. J Med Virol 2003, 71(4):518-526.
*通讯作者
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