Dr. Qingge Li
Professor in Molecular Diagnostics and Ph.D. Supervisor

Tel/Fax: 0592-2187363
E-mail: qgli@xmu.edu.cn

厦门大学理学博士（1994）
厦门大学细胞生物学与肿瘤细胞生物工程教育部重点实验室研究员（2002）
福建省化学生物学重点实验室研究员
细胞生物学方向硕士生导师
生物化学与分子生物学方向博士生导师
厦门大学分子诊断课题组负责人
厦门市卫生局医学科研与医学教育顾问
1996年9月至1997年9月，在日本昭和大学药学部和日本九州大学工学部访问研究
2000年11月至2002年3月在美国公共卫生研究所访问研究
2002年8至9月在日本早稻田大学访问研究
主持各类课题10余项，发表论文40余篇,申请专利6项。

研究兴趣：
分子诊断（遗传病，肿瘤，重大传染病等），生物纳米材料在免疫诊断及药物靶向输送的应用。

Major Interests:
Novel techniques in molecular diagnostics in genetics diseases, cancer, and serious infectious diseases. Also include nanomaterials in immunoassays and targeting drug delivery.

 分子诊断学研究方向

招收细胞生物学硕士/生化与分子生物学博士

分子诊断学是建立在分子生物学基础上的医学诊断技术，在充分借鉴现代基因组学与蛋白质组学的研究成果基础上，通过建立各种适用的检测技术将疾病相关的基因、蛋白与临床诊断紧密结合，为疾病预防，疾病预警和疗效评价服务。本方向欢迎具有生物化学、分子生物学、细胞生物学、化学生物学以及基础临床医学等各相关背景的有志者加入！

Selected Publications:

1. Heng Zhang, Ye Xu, Wei Yang, Qingge Li, Dual-Lanthanide-Chelated Silica Nanoparticles as Labels for Highly Sensitive Time-resolved Fluorometry, Chemistry of Materials 2007 (accepted)
2. Yingying Gu, Qingge Li, Real-time PCR genotyping of aldehyde dehydrogenase-2 using displacing probes, Clinical Biochemistry 2007(accepted)
3.  Qiuying Huang, Qinghua Hu, Qingge Li, Identification of eight foodborne pathogens by multicolor combinational probe coding technology in a single real-time PCR, Clinical Chemistry 2007, Aug 10; [Epub ahead of print] PMID: 17693526
4. Li Ruan, Bin Pei, Qingge Li, Multicolor real-time polymerase chain reaction genotyping of six human platelet antigens using displacing probes. Transfusion 47(9)1637-1642, 2007.
5. Ye Xu, Qingge Li, Multiple Fluorescent labeling of silica nanoparticles with lanthanide chelates for highly sensitive time-resolved immunofluorometric assays, Clinical Chemistry 53(8)1503–1510, 2007.
6. Huixin Wen, Qingge Li, Real-time PCR detection of multiple lamivudine-resistant mutations with displacing probe in a single tube, Journal of Clinical Virology 38 (4)334–340, 2007.
7. Yiqun Liao, Yangjian Cheng, Qingge Li, Preparation of nitrilotriacetic acid/Co2+-linked, silica/boron-coated magnetite nanoparticles for purification of 6×istidine-tagged proteins, Journal of Chromatography A 1143(1-2)65–71, 2007.
8. Yangjian Cheng, Jianjun Niu, Yongyou Zhang, Jianwei Huang, Qingge Li, Preparation of His-tagged Armored RNA phage particles as control for real-time RT-PCR detection of severe acute respiratory syndrome coronavirus, Journal of Clinical Microbiology 45(10), 3557–3561, 2006.
9. Qiuying Huang, Qiwei Guo, Yangjian Cheng, Qingge Li, Preparation of a Chimeric Armored RNA as a Versatile Calibrator for Multiple Virus Assays, Clinical Chemistry 52(7) 1446-1448, 2006.
10. Jinping Cheng, Yongyou Zhang, Qingge Li, Real-time PCR genotyping using displacing probes, Nucleic Acids Research 32(7): E61, 2004.
11.  Qingge Li, Guoyan Luan, Qiuping Guo, Jixuan Liang, A new class of homogeneous nucleic acid probes based on specific displacement hybridization, Nucleic Acids Research 30 (2): E5, 2002.
12.  Qingge Li, Jixuan Liang, Guoyan Luan, Molecular Beacon-based homogeneous fluorescence PCR assay for the diagnosis of infectious diseases, Analytical Sciences 16(2):245-248, 2000.
13. Qingge Li, Jingou Xu, Xianzhi Huang, Guozhen.Chen, The effects of media properties on horseradish peroxidase-catalyzed fluorogenic reaction, Talanta 41(12), 2049-2054, 1994.
14. Qingge Li, Jingou Xu, Xianzhi Huang, Guozhen Chen, Catalytic effects of Cetreyltrimethylammonium bromide on horseradish peroxidase-catalyzed fluorogenic reaction between hydrogen peroxide and p-hydroxyphenylpropionic acid, Anal. Chim. Acta. 298, 279-284, 1994.