调节生物学 Regulatory Biology 林圣彩 ShangCai Lin Ph.D

简 历: 1984年毕业于厦门大学生物系; 1985年由CUSBEA项目赴美留学；1991年获美国德克萨斯大学西南医学中心生物化学博士; 1991～1995年Howard Hughes Institute at UCSD博士后; 1995～2001年新加坡国立大学分子与细胞生物研究所实验室主任; 2001～2006年7月兼任香港科技大学生化系助理教授、副教授; 2001年至今为厦门大学生命科学学院“长江学者”、博士生导师, 2003年出任生命科学学院院长。 1984, B.Sc. Xiamen University; 1991, Ph.D., UT Southwestern Medical Center at Dallas; 1991-1995: Postdoctoral Fellow at the Howard Hughes Medical Institute, UCSD; 1995-2001: Principal Investigator, IMCB, Singapore; 2001-2006, Assistant Professor, Associate Professor, Hong Kong University of Science and Technology; 2001-Present: Professor, Cheung Kong Scholar, Xiamen University; 2003 to Present, Dean, School of Life Sciences, Xiamen University.

主要研究领域: (Research Area) 
    致力于细胞生长发育及调控机理方面的信号转导研究 
    体轴发育抑制因子Axin是Wnt信号途径的负调控子, 其变异可导致复轴及癌症发生。我们实验室发现，Axin是一种可以激活JNK MAP激酶的骨架蛋白，并独家阐明了整个信号通路的分子与生化机理，发现Axin是通过MEKK1/4以及其下游激酶MKK4/7激酶JNK。最近，我们又发现它能结合p53及其调节因子HIPK2结合，增强p53的磷酸化从而激活p53诱导细胞死亡,提供Axin抑癌作用的分子机制；我们又发现Axin也是TGF-beta通路的架构蛋白。我们对Axin活化JNK和作为抑癌因子这一系列信号通路的结构基础和分子机制有了系统的研究和成果。
    Our research lies in the broad area of the molecular mechanisms that underlie cell proliferation/differentiation, and development. We have delineated a signaling pathway, in that Axin, an axis inhibitor, binds to MEKK1/4 and activates the JNK MAP kinase via MKK4/7.　More recently, we found that Axin interacts with the nuclear serine/threonine kinase HIPK2 and enhances its kinase activity towards p53, promoting p53-dependent transcriptional activity and apoptosis. In addition, we found that Axin is also a scaffold protein for TGF-beta signaling. Axin is thus a master scaffold for multiple signaling pathways that control body development, cell proliferation and death.

代表性论文(Selected Publications)

1. Lin CR, Lin SC, Chang CP, and Rosenfeld MG.  Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 360: 765-768, 1992.
2. Lin SC, et al. Molecular basis of the little mouse phenotype and implication for cell type-specific growth (Article). Nature 364: 208-213, 1993.
3. Lin SC, et al. Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-Independent and Pit-1-dependent origins of thyrotrope.  Development 120: 515-522, 1994.
4. Kamei Y. et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403-414, 1996.
5. Zhang Y. et al. Axin forms a complex with MEKK1 and activates c-Jun N-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J. Biol. Chem. 274: 35247-35254, 1999.
6. Zhou Z. et al. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35: 49-56, 2003
7. Rui Y. et al. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23: 4583-4594, 2004
8. Liu W. et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J., 25: 1646-1658, 2006.
9. Xiong B. et al. Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Dev. Cell 11: 225-238, 2006.
10. Li Q. et al. Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res., 67: 66-74,
    2007.

课题组成员(Lab Associates)
    叶志云 (YE, Zhiyun): 学士，高级工程师 (Research  Scientist)  
    李勤喜 (Li, Qinxi): 博士，副教授 (Associate Professor)

林圣彩教授简历(SHENG-CAI LIN:CURRICULUM VITAE)
我们的实验室 http://life.xmu.edu.cn/linlab