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黄河清 教授,博导 教育部高等学校优秀骨干教师。1989.10-1992.9年在美国Brigham Young大学化学与生物化学系从事博士后研究工作;1991.9-1992.4年在美国Illinois大学贝克曼研究院从事神经结构与功能研究。
电话:(0592)-2183255/2184614 电子信箱:hqhuang@xmu.edu.cn
研究兴趣: 拓展铁蛋白结构与新功能系列研究,研制肿瘤诊断试剂盒和纳米多肽核-铁蛋白口服药物。选用蛋白质组学及其相关分析技术研究海洋软体动物中枢神经系统和人血清中的功能蛋白质组的结构与功能,开展诊断肿瘤疾病新标志物和医治神经疾病药物(包括结构分析)的研究。
Huang He-Qing Professor in Bio-chemistry, Chemical Biology and Analytical Biochemistry
Research Interests: The research focus on the struc- ture and function of ferritins coming from the different sources, and on the oral drug of ferritin-peptide core with nanometer size. We are actively studying proteomics of the central nervous systems from the various molluscs by the technique of NMR, ICP-MS, HPLC and ESI-Q-TOF.
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Huang He-Qing Professor in Biochemistry, Chemical Biology and Analytical Biochem.
近年来,承担国家自然科学基金和科技部基金项目:①铁蛋白反应器连续监测内海流动水域污染程度;②生物电化学反应器连续内海流动水域污染程度;③鱼虾蛋白组技术监测内海流动域污染程度;④纳米多肽核-铁蛋白控制多肽机理的研究. 课题组部分研究论文代表作
⑴ Huang HQ, Cao TM, et al., Characteristics of Trapping Copper Ions with Scrolled Ferritin Reactor in the Flowing Seawater. Environmental Science and Technology. 2004, 38:2476-2481.
⑵ Huang HQ, Xiao ZQ, et al., Characteristics of Structure, Composition, Mass Spectra, Kinetics of Iron Release from the ferritin of Shark Liver (Sphyma Zygaena). Biophysical Chemistry, 2004, 111:213-222.
⑶ Huang HQ, Lin QM et al., Kinetics of Iron Release from Pig Spleen Ferritin with Platinum Electrode Reduction. Biophysical Chemistry, 2002, 97:17-27
⑷ Huang HQ, Lin QM, et al., Construction of Ferritin Reactor: An Efficient Means for Trapping Various Heavy Metals Ions in Flowing Seawater Journal of Protein Chemistry, 2000,19:441-447
⑸ Huang HQ, Lin QM et al., Studies on the heme and H2-uptake reaction from Azotobacter vinelandii bacterial ferritin/ Bioelectrochemistry and Bioengergetics, 1999,48:87-93
⑹ Huang HQ, Watt GD, et al., Fe2+ Binding to Horse Spleen Holo-ferritin. Biochemistry, 1993,32:1681-1687
硕士和博士研究生部分研究论文代表作
⑺ Kong B, Huang HQ, et al., Purifiaction, Electrophoretic Behavior, and Kinetics of Iron Release of Liver Ferritin of Dasyatis Akajei. Journal of Protein Chemistry, 2003, 32:61-70
⑻ Hummon BA, Huang HQ, et al., An Novel Prohormone Processing Site in Aplysia Californica: the Leu-leu Rule. Journal of Neurochemistry, 2002,82:1398-1405
⑼ Wang QL, Huang HQ, et al, Progress in Structural and Functional Study of Nanometer Protein Shell of the ferritin. Progress in Chemistry, 2004, 16:516-520
本科生部分研究论文代表作
⑽ 陈平, 黄河清等. 混合蛋白质体系中魟鱼和海兔肝铁蛋白释放铁的动力学研究. 《生物物理学报》2004,20:285-289。
⑾ 颜利 黄河清等. MALDI-TOF质谱和电子光谱技术研究人血清铁蛋白释放铁的动力学. 《高等学校化学学报》 2004,25:1-4 |