今天是：  

 

 

主要从事:

 细胞生长、发育、凋亡等相关功能基因及调控机理方面的研究，实验室于2001年8月开始建设，现有副教授2名，博士生5名（已毕业博士生2名），硕士生15名。

承担的研究课题有：

  1. 国家杰出青年科学研究基金项目“生物分子的相互作用” （2002.1～2005.12）80万
  2. 福建省重大科技项目“Axin在控制细胞生长及应激反应两种途径中双功能性转换机制及结构基础” （2002.6～2005.6）70万
  3. 国家高技术研究发展计划（863计划）项目“对虾G蛋白信息途径中功能基因的克隆与功能鉴定” （2002.10～2004.10）40万
  4. 国家自然科学基金重大研究计划项目“翻译后蛋白修饰Sumoylation 对Axin生物学信息传递调节机理”（2003.1～2006.12）60万
  5. 厦门科技计划项目“Axin调节细胞内致癌因子beta-catenin分布和水平的新机制”（2004.5～2006.12）8万
  6. 国家自然科学基金面上项目“Axin与多种抑癌蛋白因子的复合体的机理和生物学功能” （2004.1～2006.12）20万
  7. 福建省基金重点项目“Cdk5调节致癌因子beta-catenin在细胞内分布的机制”（2005.5～2008.5）15万
  8. 厦门大学科研项目“细胞坏死的分子机理研究”（2005.6～2009.12）300万
  9. 海外青年学者合作研究基金“生物分子的结构与功能、合成机理及调节过程”（2006.1～2008.12）40万
  10. 国家基金面上项目“在Axin诱导的细胞凋亡中，PML是必须的” （2006.1～2008.12）28万
  11. 教育部科技创新工程重大项目培育资金项目“信号转导架构蛋白Axin介导的JNK通路对脑发育的调控研究”（2006.1～2007.12）40万

以厦大为第一作者单位发表的论文：

  1.  Luo, H.W., Ng, W., Jin, L.H., Ye, Z.Y., Han, J., and Lin, S.C. Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation. J. Biol. Chem. 278, 37451-8, 2003
  2. Jin, L.H., Shao, Q.J., Luo, HW, Li, Q., and Lin, S.C. Detection of the Point Mutation of the AXIN1 Gene in Colorectal Cancers. Int. J. Cancer. 107,696-9, 2003
  3. Luo, W., and Lin, S.C. Axin: a master scaffold for multiple pathways. Neurosignals 13, 99-113, 2004
  4. Wong, C.K., Luo,W., Deng, Y., Zou, H.Y., Ye, Z.Y., and Lin, S.C., The DIX Domain Protein Coiled-coil-DIX1 Inhibits c-Jun N-terminal Kinase Activation by Axin and Dishevelled through Distinct Mechanisms. J. Biol. Chem. 279, 39366–39373, 2004
  5. Li, J., Li, Q., Xie, C., Zhou, H., Wang Y., Zhang, N., Shao, H., Chan, S.C., Peng, X., Lin, S.C., and Han, J. Beta-actin is required for mitochondrial clustering and ROS generation in TNF-induced, caspase-indepndent cell death. J. Cell Sci.117, 4673-4680, 2004
  6. Luo, W., Zou, H.Y., Jin, L.H., Lin, S.Y., Li, Q.X., Ye, Z.Y., Rui, H.L., and Lin, S.C. Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280, 5054-5060, 2005
  7. Zhou, H., Zarubin, T., Ji, Z., Min, Z.,  Zhu, W., Downey, J.S., Lin, S.C., and Han, J. Frequency and Distribution of AP-1 Sites in the Human Genome. DNA Res. 12, 139-150, 2005
  8.  Xie, C.C., Zhang, N., Zhou, H., Li, J., Li, Q., Zarubin, T., Lin, S.C., and Han, J. Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells. Mol. Cell Biol. 25, 6673-81, 2005
  9. Han, J.，and Richard J Ulevitch. Limiting inflammatory responses during actication of innate immunity. Nat. Immunol. 6(12),1198-25, 2005
  10.  Zhou, H., Zheng, M., Chen, J., Xie, C.C. Kolatkar, A.R., Zarubin,T., Ye, Z., Akella, B., Lin, S.C., Goldsmith, E.J., and, Han, J. Determinants that Control the Specific Interactions between TAB1 and p38. Mol. Cell Biol. 26 (10), 3824-3834, 2006.
  11. Li, Q.X.,  Wang, X.,  Wu, X. L., Rui, Y. N., Liu, W., Wang, J.F., Wang, X.H., Liou, Y.C., Ye, Z.Y. and Lin. S.C. Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Research, 67, 66-74, 2007.
  12. Zou, H., Li, Q., Lin, S.-C., Wu, Z., Han, J., and Ye, Z. Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins. FEBS Lett., 581, 196-202, 2007.
  13. Lin, S.-C.*, and Li, Q. Axin bridges Daxx to p53. Cell Res., 17, 301-302, 2007.

与其它单位合作发表的论文

  1.  Lin, X.F., Zhao, B.X., Chen, H.Z.,Ye,X.F., Yang, C.Y., Zhou, H.Y.,  Zhang, M.Q., Lin S.C., and Wu,Q., RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells. J. Cell Sci. 117, 5609-5621, 2004
  2. Rui,Y.N., Xu, Z., Lin, S.Y., Li, Q.X., Rui, H.L., Luo, W., Zhou, H.M., Cheung, P.Y., Wu, Z.G., Ye, Z.Y., Li, P., Han, J.H., and Lin, S.C. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583-4594, 2004
  3. Liu, W., Rui, H., Wang, J.,Lin, S.Y., He, Y., Chen, C., Li, Q., Ye, Z.Y., Zhang, S., Chan, S.C., Chen, Y.G., Han, J., and Lin, S.C. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J., 25，1646-1658，25，1646-1658, 2006
  4. Jean, S.C., Yvonne, M., Nikki, A.B., Jenny, H., John, M., Rong, X.,Huamin Zhou, H., Li, Q., Han, J., and Richard J. Ulevitch Nod1-dependent control of tumor growth, PNAS  2006,103(6):1840–1845
  5. Xiong, B., Rui, Y.N., Zhang, M., Shi, K.H., Jia, S.J., Tian, T., Yin, K., Huang, H.Z., Lin, S.Y., Zhao, X. G., Chen, Y.H., Chen, Y.G., Lin, S.C*., Meng, A.M.,* (*corresponding authors). Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Developmental Cell 11, 225-238, 2006.