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5月15日学术讲座--Targeting Immune Microenvironment in Cancer Immunotherapy

发布时间:2017-05-12来源:生命科学学院点击数:16

报告题目:Targeting Immune Microenvironment in Cancer Immunotherapy

主 讲 人:唐海东 博士

             美国德州大学西南医学中心

时   间:2017年5月15日(周一)上午10:30

地   点:生命科学学院 E407学术报告厅

邀 请 人:林圣彩 教授   周大旺 教授

报告摘要Checkpoint blockade therapy has shown unprecedented success in clinical trials for treating many cancers. However, durable responses are observed in only a minority of patients. It is commonly believed that PD-L1 on tumor cells is essential to prevent T cell-mediated killing. But clinical responses were also observed in some patients that were negative for PD-L1 on tumors. By using PD-L1-deficient mouse and tumor models, we found that PD-L1 in tumor cells is dispensable for the responses to checkpoint blockade. Instead, PD-L1 in antigen presenting cells play more important roles and correlate with clinical benefits in patients. Furthermore, we demonstrate that a sufficient number of tumor infiltrating lymphocytes is a prerequisite for the response. By combining in vitro evolution and protein engineering, we developed an immunocytokine which is able to overcome tumor resistance to checkpoint blockade by recruiting lymphocytes specifically to tumor. Our studies provide new insights to the mechanisms, as well as potential strategies to improve current cancer immunotherapies.