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程通副教授

发布时间:2015-10-25来源:点击数:3921

程通,CHENG TongPh.D.

副教授,硕士生导师  Associate Professor

+86-592-2184113

E-mailtcheng@xmu.edu.cn 

1999年,厦门大学生物学专业,学士学位;

2006年,厦门大学动物学专业,博士学位;

 

研究领域(Research Area

主要从事病毒分子生物学、分子疫苗学、人源化动物模型研究。负责“国家传染病诊断试剂与疫苗工程技术研究中心”、“分子疫苗学与分子诊断学国家重点实验室”病毒疫苗与感染模型研究组的研究工作。目前研究方向包括人手足口病相关肠道病毒中和表位与广谱疫苗研究,水痘-带状疱疹病毒致病机制与新型疫苗研究,乙型肝炎病毒人源化动物模型研究。已发表60余篇科研论文,其中第一作者或通讯作者发表SCI论文15篇。已申请中国发明专利10项,国际发明专利2项,其中6项已获授权。

 

近五年主要论文(*通讯作者Corresponding author):

[1]       Xu L, He D, Yang L, Li Z, Ye X, Yu H, Zhao H, Li S, Yuan L, Qian H, Que Y, Kuo Shih JW, Zhu H, Li Y, Cheng T*, Xia N*. A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71. Scientific Reports. 2015, 5:12973.

[2]       Yang L, Li S, Liu Y, Hou W, Lin Q, Zhao H, Xu L, He D, Ye X, Zhu H, Cheng T*, Xia N. Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice. Virus Res. 2015, 210:165-168.

[3]       Liu J, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, Zhu H, Cheng T*, Xia N. A monoclonal antibody-based VZV Glycoprotein E Quantitative Assay and Its Application on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol, 2015, 99(11):4845-4853

[4]       Hou W, Yang L, Li S, Yu H, Xu L, He D, Chen M, He S, Ye X, Que Y, Shih JW, Cheng T*, Xia N*. Construction and characterization of an infectious cDNA clone of Echovirus 25. Virus Res. 2015, 205:41-44

[5]       Hou W, Yang L, He D, Zheng J, Xu L, Liu J, Liu Y, Zhao H, Ye X, Cheng T*, Xia N. Development of a coxsackievirus A16 neutralization test based on the enzyme-linked immunospot assay. J Virol Methods. 2015, 215-216:56-60

[6]       Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T*, Xia N. Protection against lethal Enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics. 2014, 4(5):498-513. (cover paper)

[7]       Yang L, He D, Tang M, Li Z, Liu C, Xu L, Chen Y, Du H, Zhao Q, Zhang J, Cheng T*, Xia N. Development of an enzyme-linked immunosorbent spot assay to measure serum-neutralizing antibodies against coxsackievirus B3. Clin Vaccine Immunol. 2014, 21(3):312-20.

[8]       Li Z, Xu L, He D, Yang L, Liu C, Chen Y, Shih JW, Zhang J, Zhao Q, Cheng T*, Xia N*. In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model. PLoS One. 2014, 9(10):e109391.

[9]       Chen L, Liu J, Wang W, Ye J, Wen L, Zhao Q, Zhu H, Cheng T*, Xia N. Development of a Varicella-zoster virus neutralization assay using a glycoprotein K antibody enzyme-linked immunosorbent spot assay. J Virol Methods, 2014, 200C:10-14.  

[10]    Mao Q1, Cheng T1, Zhu F1, Li J, Wang Y, Li Y, Gao F, Yang L, Yao X, Shao J, Xia N, Liang Z, Wang J. The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and children. PLoS One. 2013, 8(11):e79599. co-1st

[11]    Wang W, Cheng T*, Ma K, Xia D, Wang Y, Liu J, Du H, Shih JW, Zhang J, Zhao Q, Xia N. Development of a novel baculovirus titration method using the Enzyme-linked immunosorbent spot (ELISPOT) assay. J Virol Methods. 2013, 188(1-2):114-20.

[12]    Zhang T1, Cheng T1, Wei L, Cai Y, Yeo AE, Han J, Yuan YA, Zhang J, Xia N. Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct. Virol J. 2012, 9(1):118. co-1st

[13]    Zhang YL, Cheng T*, Cai YJ, Yuan Q, Liu C, Zhang T, Xia DZ, Li RY, Yang LW, Wang YB, Yeo AE, Shih JW, Zhang J, Xia NS. RNA Interference inhibits hepatitis B virus of different genotypes in vitro and in vivo. BMC Microbiol. 2010, 10:214.

[14]    Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM. Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proc Natl Acad Sci USA. 2015. pii: 201509392

[15]    Selariu A, Cheng T, Tang Q, Silver B, Yang L, Liu C, Ye X, Markus A, Goldstein RS, Cruz Cosme RS, Lin Y, Wen L, Qian H, Han J, Dulal K, Huang Y, Li Y, Xia N, Zhu H. ORF7 of Varicella Zoster Virus is a Neurotropic Factor.J Virol. 2012 , 86(16):8614-24.

[16]    Chen Y, Li C, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen PJ, Zhang J, Xia N. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity. Vaccine. 2013, 31(2):425-30.

[17]    Zhang Z, Selariu A, Warden C, Huang G, Huang Y, Zaccheus O, Cheng T, Xia N, Zhu H. Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor. PLoS Pathog. 2010, 6(7):e1000971.