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程通副教授

发布时间:2015-10-25来源:点击数:5394

程通,CHENG TongPh.D.

副教授  Associate Professor

Phone:+86-592-2184113

E-mailtcheng@xmu.edu.cn 

1999年,厦门大学生物学专业,学士学位;

2006年,厦门大学动物学专业,博士学位;

1999, B.S. Biology, Xiamen University

2006, Ph.D. Zoology, Xiamen University

 

研究领域(Research Area

主要开展病毒分子生物学、分子疫苗学和人源化动物模型研究。负责“国家传染病诊断试剂与疫苗工程技术研究中心”、“分子疫苗学与分子诊断学国家重点实验室”的病毒疫苗与感染模型研究组。目前研究方向包括:肠道病毒广谱中和表位与疫苗,水痘-带状疱疹病毒感染致病机制与新型疫苗,新型溶瘤病毒和人源化动物模型研究。已发表90余篇科研论文,其中以通讯或第一作者发表SCI论文30余篇。已获得7项中国发明专利授权,和4项美国、欧盟、日本发明专利授权。


 

近五年主要论文(*通讯作者Corresponding author):

[1]    Yuan L, Liu X, Zhang L, Li X, Zhang Y, Wu K, Cao J, Hou W, Zhang J, Zhu H, Yuan Q*, Tang Q*, Cheng T*, Xia N. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cell for the Chronic Hepatitis B Virus Infection. Frontiers in Microbiology. 2018 May 8, 9:908

[2]    Li S, Armstrong N, Zhao H, Hou W, Liu J, Chen C, Wan J, Wang W, Zhong C, Liu C, Zhu H, Xia N, Cheng T*, Tang Q*. Zika Virus Fatally Infects Wild Type Neonatal Mice and Replicates in Central Nervous System. Viruses. 2018 Jan 22, 10(1):pii:E49

[3]    Zhu R1, Cheng T1, Yin Z, Liu D, Xu L, Li Y, Wang W, Liu J, Que Y, Ye X, Tang Q, Zhao Q, Ge S, He S*, Xia N*. Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population. Emerg Microbes Infect. 2018 Jan 10, 7(1):2. co-1st

[4]    Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T*, Zhou ZH, Yan X*, Xia N*. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nature Communications. 2017,Sep 11, 8(1):505.  

[5]    Wang W, Yang L, Huang X, Fu W, Pan D, Cai L, Ye J, Liu J, Xia N, Cheng T*, Zhu H*. Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia. Virology. 2017, 512:34-38.

[6]    Wang W, Fu W, Pan D, Cai L, Ye J, Liu J, Liu C, Que Y, Xia N, Zhu H*, Cheng T*. Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localization. Virologica Sinica. 2017, 32(5):387-395

[7]    Wang W, Pan D, Fu W, Cai L, Ye J, Liu J, Liu C, Huang X, Lin Y, Xia N, Cheng T*, Zhu H*. A SCID mouse-human lung xenograft model of varicella-zoster virus infection. Antiviral Research. 2017, 146:45-53.

[8]    Li S, Zhao H, Yang L, Hou W, Xu L, Wu Y, Wang W, Chen C, Wan J, Ye X, Liang Z, Mao Q*, Cheng T*, Xia N. A neonatal mouse model of coxsackievirus A10 infection for anti-viral evaluation. Antiviral Research. 2017, 144:247-255

[9]    Wu Y, Zhu R, Xu L, Li Y, Li S, Yu H, Li S, Zhu H, Cheng T*, Xia N. A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against Enterovirus 71 and Varicella-Zoster Virus. Vaccine. 2017, 35(20):2728-2735.

[10]  Yang L, Liu Y, Li S, Zhao H, Lin Q, Yu H, Huang X, Zheng Q, Cheng T*, Xia N. A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice. Vaccine. 2016, 34:5938-5945

[11]  Yang L, Mao Q, Li S, Gao F, Zhao H, Liu Y, Wan J, Ye X, Xia N, Cheng T*, Liang Z*. A neonatal mouse model for the evaluation of antibodies and vaccines against coxsackievirus A6. Antiviral Research. 2016, 134:50-57

[12]  Wang W, Wang X, Yang L, Fu W, Pan D, Liu J, Ye J, Zhao Q, Zhu H, Cheng T*, Xia N. Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo. Virology. 2016, 491:96-105.

[13]  Zhu R, Liu J, Chen C, Ye X, Xu L, Wang W, Zhao Q, Zhu H, Cheng T*, Xia N. A highly conserved epitope-vaccine candidate against varicella-zoster virus induces neutralizing antibodies in mice. Vaccine. 2016. 34:1589-96.

[14]  Ye X, Yang L, Jia J, Han J, Li S, Liu Y, Xu L, Zhao H, Chen Y, Li Y, Cheng T*, Xia N. Development of sandwich ELISAs that can distinguish different types of coxsackievirus A16 viral particles. Appl Microbiol Biotechnol. 2016, 100(6):2809-15

[15]  Liu J, Ye X, Jia J, Zhu R, Wang L, Chen C, Yang L, Wang Y, Wang W, Ye J, Li Y, Zhu H, Zhao Q, Cheng T*, Xia N*. Serological Evaluation of Immunity to the Varicella-Zoster Virus Based on a Novel Competitive Enzyme-Linked Immunosorbent Assay. Sci Rep. 2016, 6:20577.

[16]  Yang L, Li S, Liu Y, Hou W, Lin Q, Zhao H, Xu L, He D, Ye X, Zhu H, Cheng T*, Xia N. Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice. Virus Res. 2015, 210:165-8.

[17]  Liu J, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, Zhu H, Cheng T*, Xia N. A monoclonal antibody-based VZV Glycoprotein E Quantitative Assay and Its Application on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol, 2015, 99(11):4845-53

[18]  Xu L, He D, Yang L, Li Z, Ye X, Yu H, Zhao H, Li S, Yuan L, Qian H, Que Y, Kuo Shih JW, Zhu H, Li Y, Cheng T*, Xia N*. A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71. Sci Rep. 2015, 5:12973.

[19]  Hou W, Yang L, Li S, Yu H, Xu L, He D, Chen M, He S, Ye X, Que Y, Shih JW, Cheng T*, Xia N*. Construction and characterization of an infectious cDNA clone of Echovirus 25. Virus Res. 2015, 205:41-4

[20]  Hou W, Yang L, He D, Zheng J, Xu L, Liu J, Liu Y, Zhao H, Ye X, Cheng T*, Xia N. Development of a coxsackievirus A16 neutralization test based on the enzyme-linked immunospot assay. J Virol Methods. 2015, 215-216:56-60

[21]  Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T*, Xia N. Protection against lethal Enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics. 2014, 4(5):498-513. (cover paper)

[22]  Yang L, He D, Tang M, Li Z, Liu C, Xu L, Chen Y, Du H, Zhao Q, Zhang J, Cheng T*, Xia N. Development of an enzyme-linked immunosorbent spot assay to measure serum-neutralizing antibodies against coxsackievirus B3. Clin Vaccine Immunol. 2014, 21(3):312-20.

[23]  Li Z, Xu L, He D, Yang L, Liu C, Chen Y, Shih JW, Zhang J, Zhao Q, Cheng T*, Xia N*. In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model. PLoS One. 2014, 9(10):e109391.

[24]  Chen L, Liu J, Wang W, Ye J, Wen L, Zhao Q, Zhu H, Cheng T*, Xia N. Development of a Varicella-zoster virus neutralization assay using a glycoprotein K antibody enzyme-linked immunosorbent spot assay. J Virol Methods, 2014, 200C:10-14.

[25]  Mao Q1, Cheng T1, Zhu F1, Li J, Wang Y, Li Y, Gao F, Yang L, Yao X, Shao J, Xia N, Liang Z, Wang J. The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and children. PLoS One. 2013, 8(11):e79599. co-1st

[26]  Wang W, Cheng T*, Ma K, Xia D, Wang Y, Liu J, Du H, Shih JW, Zhang J, Zhao Q, Xia N. Development of a novel baculovirus titration method using the Enzyme-linked immunosorbent spot (ELISPOT) assay. J Virol Methods. 2013, 188(1-2):114-20.

[27]  Zhang T1, Cheng T1, Wei L, Cai Y, Yeo AE, Han J, Yuan YA, Zhang J, Xia N. Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct. Virol J. 2012, 9(1):118. co-1st

[28]  Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM. Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proc Natl Acad Sci USA. 2015. pii: 201509392

[29]  Selariu A, Cheng T, Tang Q, Silver B, Yang L, Liu C, Ye X, Markus A, Goldstein RS, Cruz Cosme RS, Lin Y, Wen L, Qian H, Han J, Dulal K, Huang Y, Li Y, Xia N, Zhu H. ORF7 of Varicella Zoster Virus is a Neurotropic Factor.J Virol. 2012 , 86(16):8614-24.