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莫玮教授博导

发布时间:2015-10-23来源:点击数:12604

莫玮   Mo,Wei Ph.D.

教授博导

神经发育与肿瘤

(Developmental and Cancer Biology in Neural System

课题组组长

电话   :  +86-592-2880342

E-mail:  wmo@xmu.edu.cn

 

2002年毕业于浙江大学生物学系生命科学院,获理学学士学位;

2008年毕业于中科院上海生化细胞所,获博士学位;

2009年至2014年在美国西南医学中心从事博士后研究;

20148-至今,厦门大学生命科学学院教授/课题组长;

2002B.S, Zhejiang University

2008, Ph.D, Shanghai institution of biochemistryand cell biology, SIBS, CAS

2009-2014 Postdoc fellow, UT Southwestern Medical Center, Dallas, TX, USA

2014- Present Professor, School of Life Sciences, Xiamen University

2015   入选中组部青年千人计划

2015   入选闽江学者特聘教授


研究领域(Research Area)

利用小鼠模型,研究1)神经性肿瘤中的肿瘤干细胞对肿瘤生成及预后的影响。2)组蛋白甲基化与染色质重塑在神经系统发育和再生中的作用。

One direction in our lab is to investigate the role of cancer stem cells within cancers in central and peripheralneural system. We are also interested in the epigenetic modifications during CNS and PNS development and regeneration, especially chromatin remodeling by histone methylation.

 

代表性论文( Selected publications)

1.Mo W, Chen J, Patel A, Parada LF. (2013) CXCR4/ CXCL12 mediate autocrine cell cycle progression in NF1- associated malignant peripheral nerve sheath tumors.Cell 152, 1077-90.

2.Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen X, Hui L, Huang R, Hu G. (2008) Nuclear beta-arrestin1 functions as a scaffold for the dephosphoryation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell 31, 695-707.

3.Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ.(2013).Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 74(2):586-97.

4.Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J, Parada LF.(2014). NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev. Nov 1;28(21):2407-20.