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张亮副教授

发布时间:2014-12-20来源:点击数:5321

 

张亮 Zhang Liang, Ph.D.

副教授

课题组组长

电话:+86-592-2880343

E-mail: LZHANGXMU@xmu.edu.cn

 

2003年,武汉大学获学士学位;

2008年,中国科学院上海生命科学院获博士学位;

2008-2009年,中国科学院上海生命科学院助理研究员

2009-2014年,美国德州大学西南医学中心博士后;

2014年至今,厦门大学生命科学学院,副教授。

 

2003, B.S., Wuhan University;

2008, Ph.D., Shanghai Institutes for Biological Science, Chinese Academy Science

2008-2009, Assistant Investigator, Shanghai Institutes for Biological Science, Chinese Academy Science

2009-2014, Postdoctoral Fellow, UT Southwestern Medical Center, Dallas, USA

2014-Present, Associate Professor, School of Life Sciences, Xiamen University

 

研究领域(Research Area

核糖核酸在细胞核中被转录,而蛋白质在细胞质中被翻译合成。蛋白质与核酸通过核孔复合体实现细胞核与细胞质之间的穿梭。核质转运对于在正常和病理状态下的细胞都具有重要的调节功能。实验室的研究兴趣集中于核质运输在机体发育过程以及抗病毒防御中的功能。

 

Our laboratory studies the functions of nucleo-cytoplasmic trafficking during body development and antiviral defense. mRNA is transcribed in nucleus and transported to cytoplasm for translation. Proteins such as transcription factors need to be transported into nucleus to exert their functions. The trafficking of proteins and mRNA into and out of nucleus occurs through Nuclear Pore Complex (NPC). We mainly focus on whether and how nucleo-cytoplasmic trafficking regulates body development and innate immunity.

 

代表性论文 (Selected Publications)

1.     Sharon K.Kuss, Miguel A.Mata, Liang Zhang, BeatrizM.Fontoura (2013) Nuclear Imprisonment: viral strategies to arrest host mRNA nuclear export. Viruses2013, 5(7), 1824-49

2.     Priyarata Das, Xiaoyi Deng, Liang Zhang, Michael G.Roth, Beatriz M.A. Fontoura, Margaret A. Phillips and Jef K. De Brabander (2013) SAR-based optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Antiviral Activity. ACS Medicinal Chemistry Letters  April 24, 2013 4(6):517-521

3.     Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, Mckay RM, Lev D, Le LQ, Parada LF (2013) CXCR4/ CXCL12 mediate autocrine cell cycle progression in NF1- associated malignant peripheral nerve sheath tumors. Cell 152(5):1077-90.

4.     ZhangL, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM. (2012) Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. Journal of Cell Biology; 196(3):315-26 Featured and highlighted by Journal of Cell Biology Feb, 2012