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张蕾助理教授

发布时间:2015-07-20来源:点击数:4262

张蕾  Zhang Lei, Ph.D.

助理教授

话:15960285971

E-mail: zhanglei@xmu.edu.cn

 

20066月,湖南师范大学,理学学士

20096月,湖南师范大学,理学硕士

201210月,厦门大学,理学博士

201212 – 至今,厦门大学生命科学学院,助理教授

 

Hunan Normal University.  BS. 2006

Hunan Normal University.  MS. 2009

Xiamen University. PhD. 2012

December 2012- present: Assistant Professor, School of Life Sciences, Xiamen University

 

研究领域 (Research Area)

 胰岛素信号通路对应激刺激的调控及在衰老和衰老相关疾病中的功能,以及该通路与其他信号通路之间的相互应答。鉴定调控细胞周期,细胞分化,细胞凋亡,细胞自噬的关键分子和信号通路,并阐明其分子机理。

The main interest of the lab is the understanding of stress response regulated by insulin signaling pathway. We are particularly interested in studying the role of FOXO transcription factors in response to various types of stress, including oxidative stress, DNA damage and nutrient deprivation. FOXO transcription factors have been described as longevity factors in both worms and flies. Whether it holds the same function in mammals is not clear. Moreover, several lines of evidence suggest FOXOs as tumor suppressors, but the critical downstream mediators are unknown. We will employ cellular biochemical and molecular biological approaches to address these questions. Hopefully our studies will provide insights into the molecular mechanisms in human aging and age-related diseases.

 

代表性论文(Selected Publications)

1Zhang L, Mei Y, Fu N Y, Guan L, Xie W, Liu H H, Yu C D, Yin Z, Yu V C, and You H*.  TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.Proc Natl Acad Sci USA, 109(51), 20937-20942, 2012.

2Mei Y, Wang Z, Zhang L (co-first author), Zhang Y, Li X, Liu H, Ye J, You H*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA.Proc Natl Acad Sci USA.  109(13), 4898-4903, 2012

3Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak T W*, and You H*. Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1. Proc Natl Acad Sci USA. 109(15), 5717-5722, 2012.

4Ma S, Huang W, Zhang L, Zhao S, Tong Y, Liu Z, Sun L, Chen H, and Luo C*. Germ cell-specific DNA methylation and genome diploidization in primitive vertebrates. Epigenetics6(12), 1471-1480. 2011