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杨春燕助理教授

发布时间:2015-08-20来源:点击数:3992

杨春燕 YANG Chunyan, Ph.D.                             

助理教授

话:+86-592-2181560

E-mail: yangchunyan@xmu.edu.cn

 

2001.9-2005.7,北京师范大学/化学学院,学士

2005.9-2012.6,厦门大学/生命科学学院,博士

2012.7-至今,厦门大学/生命科学学院,助理教授

2001.9-2005.7, Beijing Normal University/College of Chemistry, B.S.

2005.9-2012.6, Xiamen University/School of life sciences, Ph.D.

2012.7-present, Xiamen University/School of life sciences, Assistant Professor

 

研究领域(Research Area

主要通过蛋白晶体衍射的方法及生物化学、细胞生物学等手段,对肿瘤相关信号转导途径中的重要蛋白质的结构与功能机理进行研究。

 

Our study focuses on understanding structure-function relationships of proteins which play key roles in tumorigenesis using a variety of experimental and computational approaches ranging from X-ray crystallography to biochemistry and molecular biology.

 

代表性论文(Selected Publications)

1.    Chunyan Yang, Huirong Pan, Minxi Wei, et al. Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts. Protein Sci. 2013 Mar; 22(3): 314-26

2.    Xuhua Tang*, Chunyan Yang*, Ying Gu, et al. Structural basis for the neutralization and genotype specificity of hepatitis E virus (*co-first author). Proc Natl Acad Sci U S A, Jun 21, 2011, 108(25): 10266-71

3.    Shaowei Li, Xuhua Tang, J. Seetharaman, Chunyan Yang, Ying Gu, Jun Zhang, Hailian Du, J. Wai Kuo Shih, Choy-Leong Hew, J. Sivaraman, Ningshao Xia. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain Is Essential for Virus–Host Interaction. Plos Pathogens, 2009 August; 5(8): 1-10.

4.    杨春燕, 李少伟, 王晋等. 大肠杆菌来源的人乳头瘤病毒11型病毒样颗粒的制备及其免疫原性. 微生物学报. 2009, 49 (11): 1527-1533.

5.    Fengxia Liu, Junhui Xiong, Sundaramurthy Kumar, Chunyan Yang, et al. Structural and biophysical characterization of Mycobacterium tuberculosis dodecin Rv1498A. J Struct Biol, 2011, 175: 31-38

6.    Hai Yu, Shaowei Li, Chunyan Yang, et al. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model, 2011, 17: 987-995

7.    Kunyu Yang, Shaowei Li, Fangping He, Jiannan Zhang, Minxi Wei, Huirong Pan, Chunyan Yang, Junhui Xiong, Jun Zhang, Ningshao Xia. Expression and purification of soluble HIV-1 envelope glycoprotein gp160 mutant from Saccharomyces cerevisiae. J Biosci Bioeng. 2009 Jul; 108(1):5-10.

8.    YuanQing Yan, Shaowei Li, Chunyan Yang, Wenxin Luo, Mingqiao Wang, Yixin Chen, Haifeng Luo, Ting Wu, Jun Zhang, Ningshao Xia. Prediction of a commin neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking. Chinese Science Bulletin, 2008 March; 53(6):868-877