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李晓彤教授

发布时间:2015-11-26来源:点击数:9218

  

李晓彤教授李晓彤LI Xiaotong, Ph.D.

教 授

  话:+86-592-2188250

E-mailxtli@xmu.edu.cn

 

1982, BS., Xiamen University, China;

1985, MS, Xiamen University, China;

1995, Ph.D, Duke University, Durham, USA;

1996-2002, Postdoctoral fellow, Harvard Medical School, USA;

2002-2008, Principal investigator in several biotech companies in US;

2008– present, Professor, School of Life Sciences, Xiamen University, China.

 

研究领域(Research Area

我们以整合性抗体杂交瘤技术为平台,为生物医学研究领域提供多项技术服务,此平台的研发成果已在国际一流学术杂志发表。此外,我们还致力于肿瘤免疫诊断试剂及肿瘤抗体药物的研发工作。

Our hybridoma and antibody lab was established with integrated antibody production and purification technologies to assist the research community in School of Life Sciences at Xiamen University and others since 2008. We produce both polyclonal and monoclonal antibodies starting from peptides, proteins or name of the gene. Antibodies we produced already led to important discoveries published on some top journals such as Science and Cell affiliated journal.

Beyond providing high quality antibody services to our research community, we are also focusing on developing special antibodies for cancer drug development and cancer diagnosis with selected targets based on our long-standing experience and interest in cancer drug discovery and cancer research.

 

服务内容Our services

多抗和单抗的研发和生产,抗体纯化,抗原设计和合成,抗体标记,试剂盒研发,基因合成,重组蛋白纯化和生产,大规模哺乳动物细胞培养等。

Polyclonal Antibody Development; Monoclonal Antibody Development; Antibody Purification; Antigen Design and Synthesis; Customized Antibody Labeling; Diagnostic Kit Development; Gene Synthesis, Protein Production and Purification; Large Scale of Mammalian Cell Culture and Production

 

代表性论文(Selected Publications

1.     Wu ZH, MK Lu, LY Hu, X Li*. Praziquantel Synergistically Enhances Paclitaxel Efficacy to Inhibit Cancer Cell Growth. PLOS ONE, 7(12), 2012 .

2.     Wu ZH, LY Hu, DQ Xu, X Li*.  A cell-based assay for screening spindle checkpoint inhibitors.Assay and Drug Development Technologies, 10: 344-352, 2012.

3.     Lin SY, TY Li, Q Liu, C Zhang, X Li, Y Chen, et al,. GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy.Science, 336:477-481, 2012.

4.  Yang Y, YT Ding, HT Gong, ZJ Yu, X Li*. Expression and urification of mucin 16; preparation and characterization of anti-mucin 16 monoclonal antibody.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , 28: 960-963, 2012.

5.  Ding HD, ZM Lin,Y Yang, ZJ Yu, HT Gong, X Li* Characterization of NSE monoclonal antibodies and establishment of a double-antibody sandwich ELISA assay.Zhongguo Mianyixue Zazhi , 28 (10) 922-925, 2012.

6.    Hikasa H, J Ezan, K Itoh, X Li, et al,. Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification, Developmental Cell, (19): 521-532, 2010.

7.    Chen CR, W Wang, HA Rogoff, X Li, et al,. Dual Induction of Apoptosis and Senescence in Cancer Cells by Chk2 Activation: Checkpoint Activation as a Strategy against Cancer. Cancer Research, 65: 6017-6021, 2005.

8.    Adams PD, X Li, et al,. Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Molecular and Cellular Biology, 19: 1068- 1080, 1999.

9.     Li X, RB Nicklas. Mitotic forces control a cell cycle checkpoint. Nature, 373: 630-632, 1995.