欢迎访问厦门大学生命科学学院官方网站

陈灿和教授级高工

发布时间:2016-05-12来源:点击数:6301

陈灿和教授陈灿和 CHEN Canhe, Ph.D. 

 

  +86-0592-2182609

E-mail: chench@xmu.edu.cn

 

 

1988/09-1992/07  厦门大学生物系,学士

1992/09-1995/07  厦门大学生物系,硕士

1995/10-2001/03  新加坡国立大学/分子与细胞生物学研究院,博士

2001/04-2002/03  新加坡国立大学/分子与细胞生物学研究院,博士后研究员

2002/04-2005/12  新泽西医科和牙科大学/高级生物技术与医学中心,博士后研究员

2006/02-2009/08  新加坡国家科技研究局/分子与细胞生物学研究院, 博士后研究员

2009/09-现在     厦门大学/生命科学学院,教授

1988/09-1992/07     Xiamen University , B.Sc.

1992/09-1995/07     Xiamen University,  M.Sc.

1995/10-2001/03     IMCB/National University of Singapore (NUS), Ph.D.

2001/04-2002/03  Institute of Molecular and Cell Biology (IMCB)/NUS, Research Fellow

2002/04-2005/12   Center for Advanced Biotechnology and Medicine, Robert Wood Johnson Medical School-Uiversity of Medicine and Dentistry of New Jersey, Postdoctoral Fellow

2006/02-2009/08  IMCB, Agency of Science Technology and Research (A-star), Singapore, Senior Research Fellow

2009/09-present    School of Life Sciences, Xiamen University, Professor

 

研究领域(Research Area)

本课题组致力于研究信号转导通路在胚胎发育及肿瘤发生过程中的作用和机理以及调控中心粒及其衍生物纤毛的生物发生机制。我们以斑马鱼等作为模型,利用原位杂交、吗啉基寡核苷酸反义RNA等技术研究Wnt信号通路的相关因子在胚胎早期发育的体轴形成过程中作用;并运用生化、分子细胞生物学等技术从分子水平阐释这些因子发挥作用的调控机制。同时,我们还利用细胞和斑马鱼作为模型来鉴定参与中心粒复制和纤毛长度调节的蛋白,研究这些蛋白在中心粒复制和纤毛生成过程中的作用,以及这些蛋白在脊椎动物的发育、遗传疾病及肿瘤的发生过程中的功能。这些研究将为人们对疾病发生规律的认识提供重要的理论依据。

Our research group uses biochemical, molecular and genetic tools to study signaling pathways and biogenesis of centrome and its derivative cillia, which are involved in development and tumorigenesis in vertebrate systems. We are using the zebrafish (Danio rerio) system to investigate the body plan formation during embryogenesis and the genetic programming of organelles, such as cilia and kidney; we are also using cell culture systems to examine molecular mechanisms underlying various phenotypic abnormalities.  Our aim is to reveal how the signal transduction pathways like Wnt can be integrated into the developmental programs leading to the formation of organelles.

 

代表性论文(Selected Publications)

1.     Yu X, Lau D, Ng CP, Roy S. Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development. 138: 487-94, 2011.

2.     Yu X, Ng CP, Habacher H,Roy S.. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics,40: 1445-1453, 2008.

3.     Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW. The Vg1-related protein GDF3 regulates Nodal expression in the pre-gastrulation mouse embryo. Development, 133: 319-329, 2006.

4.    Chen C, and MM Shen. Two modes of inhibition of Nodal signaling by Lefty proteins. Current Biology,14: 618-624, 2004.

5.     Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM. Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.Science, 298: 1996-1999, 2002.

6.     Chen, C., Wang, H., Fong, C.W., and Lin, S.C. (2001).  Constitutive and ligand-dependent phosphorylation of RGS16. FEBS Lett. 504:16-22.

7.     Chen, C., Seow, K.T., Guo, K., Yaw, L.P., Lin, S.C. (1999).  The membrane association domain of RGS16 contains unique amphipathic features that are conserved in RGS4 and RGS5.  J Biol Chem. 274:19799-19806

8.     Chen, C., and Lin, S.C. (1998).  The core domain of RGS16 retains G-protein binding and GAP activity in vitro, but is not functional in vivo.  FEBS Lett. 422: 359-362.

9.     Chen, C., Zheng, B., Han, J., and Lin, S.C. (1997).   Characterization of a novel mammalian RGS protein that binds to G proteins and inhibits pheromone signaling in yeast.  J Biol Chem. 272: 8679-8685.

10.  Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J.A., Lin, S., and Han, J. (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  J Biol Chem.  271: 17920-17926.

Lab Associate

Dr. YU Xianwen (余娴文),  Associate Professor