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李少伟教授博导

发布时间:2015-11-25来源:点击数:9307

 

李少伟教授

李少伟,博士  LI Shaowei, Ph.D.

教授,博士生导师 Professor

结构疫苗学 (Structural Vaccinology)

话:+86-592-2880620

真:+86-592-2181258

E-mailshaowei@xmu.edu.cn

 

简历 (Education and Work experience)

1998年,厦门大学生物化学专业,学士学位;

2003年,厦门大学生化与分子生物学/动物学专业,博士学位;

2003年,厦门大学生命科学学院讲师;

2006年,厦门大学生命科学学院副教授;

2011年,厦门大学生命科学学院教授、博士生导师。

B.S.  Biochemistry, Xiamen University, 1998

Ph.D. Biochemistry&Molecular Biology/Zoology, Xiamen University, 2003

Lecturer, School of Life Sciences, Xiamen University, 2003

Associate Professor, School of Life Sciences, Xiamen University, 2006

Professor, School of Life Sciences, Xiamen University, 2011


 

研究领域 (Research Area)

基因工程疫苗研究与开发

重要传染病病毒免疫表位的结构和功能研究

基于结构的分子模拟和分子设计

Research and development of recombinant human vaccine

Structural basis and functional implication for underlying immune epitopes of key infectious viruses

Structure-based molecular simulation and rational design for vaccine


代表性论文(Selected Publications)(* Corresponding author)

1.Pan H#, Li Z#,Wang J, Song S, Wang D, Wei M, Gu Y, Zhang J, Li S*, Xia N*, Bacterially expressed human papillomavirus type 6 and 11 bivalent vaccine: Characterization,antigenicity and immunogenicity. Vaccine, 2017. 35(24):3222-3231.

2.Wang D#, Fan F#, Li Z, Liu X, Song S, Wei S, He M, Lin Y, Li Z, Wei M, Yu H, Gu Y, Li S*, Xia N. Stop codon mutagenesis for homogenous expression of human papillomavirus L1 protein in Escherichia coli. Protein Expr Purif. 2017 May;133:110-120.

3.Li Z#, Yan X#, Yu H#, Wang D, Song S, Li Y, He M, Hong Q, Zheng Q, Zhao Q, Gu Y, Zhang J, Janssen M E, Cardone G, Olson N H, Baker T S*, Li S*, Xia N, The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction. Structure, 2016. 24(6): 874–885.

4.Zhang X#, Wang K#, Lin Q#, Zheng M, Li Q, Li T, Hong Q, Zheng Q, Yu H*, Gu Y, Li S*, Xia N*, A shared N-terminal hydrophobic tail for the formation of nanoparticulates. Nanomedicine, 2016 Sep;11(17):2289-303.

5.Gu Y#, Tang X#, Zhang X, Song C, Zheng M, Wang K, Zhang J,Ng MH, Hew CL, Li S*, Xia N*,Sivaraman J* .Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody. Cell Res. 2015 May;25(5): 604-620.

6.Li S, Zhang J, Xia N*. Lessons from hepatitis E vaccinedesign. Curr Opin Virol. 2015Apr; 11:130-136. 

7.Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, Xin L, Wei M, Kong Z, Yu H, Gu Y, Zhang J, Li S*, Xia N*. Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody. PLoS One. 2015 Apr 23;10(4):e0123944. 

8.Gu Y, Cao F, Wang L, Hou W, Zhang J, Hew CL, Li S*, Yuan YA*, Xia N*. Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr 19;8(4):e61314. 

9.Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, Zhang J, Li S*, Xia N*.Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts. Protein Sci. 2013 Mar;22(3):314-26.

10.Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL, Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10266-71. Epub 2011 Jun 3. 

11.Yu H, Li S*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model. 2011 May;17(5):987-95. Epub 2010 Jul 14. 

12.Yang K, Li S*, He F, Zhang J, Wei M, Pan H, Yang C, Xiong J, Zhang J, Xia N. Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutant from Saccharomyces Cerevisiae. J Biosci Bioeng. 2009 Jul;108(1):5-10.

13.Li S#, Tang X#, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction. PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7. 

14.Yan Y, Li S*, Yang C, Luo W, Wang M, Chen Y, Luo H, Wu T, Zhang J,  Xia N. Prediction of a common neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking.Chinese Science Bulletin2008.53(1).

15.Li S, Zhang J, He Z, Gu Y, Liu R, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid. J Biol Chem. 2005 Feb 4;280(5):3400-6. Epub 2004 Nov 22.

16.Li S, Zhang J, Li Y, Ou S, Huang G, He Z, Ge S, Xian Y, Pang S, Ng M, Xia N*. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine. 2005 Apr 22;23(22):2893-2901. 



荣誉、奖励(Honors and awards)

2011年入选教育部新世纪优秀人才,2011年福建省杰出青年基金、2010年厦门市杰出青年基金;主持国家自然科学基金、“863”重点项目子课题、新药创制重大专项及滚动项目等课题;获得国家科技进步二等奖、国家技术发明二等奖、中国高校科技进步一等奖等;申请国家发明专利17项,国际发明专利8项,获得授权5项;作为主要成员研制出戊肝疫苗、宫颈癌疫苗、尖锐湿疣疫苗、艾滋诊断试剂等新药。


WIPO-SIPO      Award for Chinese Outstanding Patented Invention (2012)

State      Technological Invention Award (2010)

State      Scientific and Technological Progress Award (2001)