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陈清西教授博导

发布时间:2016-05-15来源:点击数:15825

 

陈清西教授陈清西  CHEN Qingxi, Ph.D

厦门大学特聘教授,博士生导师

分子酶学Molecular Enzymology

课题组组长

http://121.192.179.196/cqxlab

  话:+86- 592-2185487

  真:+86-592-2185487

E-mailchenqx@xmu.edu.cn

 

1982.1毕业厦门大学动物学专业,学士学位;

1985.1毕业厦门大学生物化学专业,硕士学位;

1999.7毕业清华大学生物化学与分子生物学专业,理学博士学位;

2000.12002.2在美国加州Berkeley大学工作2年。

1998年至今,厦门大学生命科学学院,教授;

1982, BSc., Xiamen University

1985, MSc., Xiamen University;

1999, Ph.D., Tsinghua University, Biochemistry & molecular biology;

2000-2002, Visiting Scholar, University of California, Berkeley U.S.A;

1982-Present: Xiamen University. Lecturer (1986), Associate Professor (1992), Professor (1998).

 

研究领域(Research Area

主要从事酶的结构与功能、酶作用动力学、抑制动力学、抑制作用机理及功能酶的基因克隆等研究;抗癌活性多肽的分离纯化及作用机理的研究;酪氨酸酶抑制剂的分子设计及作用机理与应用的研究;我们已合成系列的酪氨酸酶抑制剂,包括缩氨基硫脲化合物、半胱氨酸席夫碱化合物、肉桂酸衍生物、3.4-二羟基苯甲酸烷基酯等系列化合物,研究它们对酪氨酸酶的抑制效应及动力学,探讨它们在果蔬保鲜和生物杀虫中的应用。5年发表研究论83篇,其中SCI39篇(JCR一区16篇、二区7篇),申请9个专利,其中8个已获得证书.

Our research areas focus on the structure and function of enzyme, inhibition/inactivation kinetics, regulation mechanism of enzyme activity and enzyme gene clone. We have made progress in the design of tyrosinase inhibitors and elected to characterize a number of new tyrosinase inhibitors. We have synthesized a series of tyrosinase inhibitors, including thiosemicarbazone compounds, cysteine schiff base compounds, cinnamic acid derivatives, alkyl 3,4-dihydroxybenzoates esters. We not only study their inhibitory effects and kinetics, but also investigate them using in the fruit and vegetable preservation and insecticide application.

 

代表论文(Selected Publications

1. Huang GF, Wu XB*, Bai LP, Liu K, Jiang LJ, Long MN, Chen QX*. Improved O2-tolerance in variants of a H2-evolving [NiFe]-hydrogenase from Klebsiella oxytoca HP1. FEBS Lett. 2015, 589(8): 910-8.

2. Gui-Li Huang1, Wei Zhang2, Hong-Yue Ren3, Xue-Ying Shen1, Qing-Xi Chen* and Dong-Yan Shen*. Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β-catenin and nuclear factor-kB pathways. Cancer Science. 2015, 106(11): 1515–1523.

3. Cui Y, Liang G, Hu YH, Shi Y, Cai YX, Gao HJ, Chen QX, Wang Q*. Alpha-substituted derivatives of cinnamaldehyde as tyrosinase inhibitors: inhibitory mechanism and molecular analysis. J. Agric. Food Chem. 2015, 63(2): 716–722.

4. Feng Yu#, Yu-Long Jia#, Hui-Fang Wang, Jing Zheng, Yi Cui, Xin-Yu Fang, Lin-Min Zhang, and Qing-Xi Chen*. Synthesis of Triazole Schiff's Base Derivatives and Their Inhibitory Kinetics on Tyrosinase Activity. PLoS One. 2015, 10(9): e0138578.

5. Wei Song, Ling Tian, Shan-Shan Li, Dong-Yan Shen, Qing-Xi Chen. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells. FEBS Letters. 2014, 588(3): 422–428.

6. Zhizhen Pan, Lian Xu, Yujing Zhu, Huai Shi, Zheng Chen, Meichun Chen, Qingxi Chen*, Bo Liu*. Characterization of a new cry2Ab gene of Bacillus thuringiensis with high insecticidal activity against Plutella xylostella L. World Journal of Microbiology and Biotechnology. 2014, 30(10): 2655-2662.

7.Apoptosis Induced by Aqueous Extracts of Crocodile Bile in Human Heptacarcinoma SMMC-7721.Wei Song, Shan-Shan Li, Ping-ping Qiu, Dong-Yan Shen, Ling Tian, Qiu-Yan Zhang, Long-Xing Liao, Qing-Xi Chen*. Applied Biochemistry and Biotechnology. 2013, 170(1): 15-24.

8. Huang GL1, Luo Q, Rui G, Zhang W, Zhang QY, Chen QX, Shen DY*. Oncogenic Activity of Retinoic Acid Receptor γ Is Exhibited through Activation of the Akt/NF-κB and Wnt/β-Catenin Pathways in Cholangiocarcinoma. Mol Cell Biol. 2013, 33(17): 3416-25.

9. Huang QS, Xie XL, Liang G, Gong F, Wang Y, Wei XQ, Wang Q, Ji ZL, Chen QX*. The GH18 Family of Chitinases: their domain architectures, functions, and evolutions. Glycobiology. 22: 23-34, 2012. (*Corresponding author).

10. Chai WM, Shi Y, Feng HL, Qiu L, Zhou HC, Deng ZW, Yan CL, Chen QX*. NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from (Bojer ex Hook.) Raf. and their bioactivities. J Agric Food Chem. 2012, 60: 5013-5022.

11. Pan ZZ , Li HL , Yu XJ , Zuo QX , Zheng GX , Shi Y, Liu X, Lin YM , Liang G, Wang Q, Chen QX*. Synthesis and Antityrosinase Activities of Alkyl 3,4-Dihydroxybenzoates. J Agric Food Chem. 2011, 59: 6645-6649.

12. Zhang JP, Hu YH, Wang Q, Wang W, Wang Y, Yan JH, Chen QX*. Inhibitory kinetics of β-N-Acetyl-D-glucosaminidase from green crab (Scylla Serrata) by Zinc ion. J Agric Food Chem. 2010, 58: 8763-8767.

13. Huang QS, Yan JH, Tang JY, Tao YM,Xie XL, Wang Y, Wei XQ, Yan QH, Chen QX*. Cloning and tissue expressions of seven chitinase family genes in L. vannamei. Fish Shellfish Immunol. 2010, 29: 76-82.

14. Han P, Kang JH, Li HL, Hu SX, Lian HH, Qiu PP, Zhang J, Li WG, Chen QX*. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression. Biochem Biophys Res Commun. 2009, 385: 251-256.

 

荣誉、奖励及参加学术团体的情况(Honors and Awards, Professional service)

2003年入选教育部跨世纪人才,2009年被遴选为厦门大学特聘教授。现任中国生物化学与分子生物学学会理事;中国酶学专业委员会副主任;中国蛋白质专业委员会中国农业生物化学与分子生物学常务理事;福建省生物化学与分子生物学学会副理事长;厦门市生物化学与分子生物学副理事长兼秘书长;《厦门大学学报(自然科学版)》副主编、《中国生物化学与分子生物学学报》、《生命的化学》、《基因组学与应用生物学》编委。

2009年度福建省科学技术进步奖三等奖-“多酚氧化酶抑制剂用于新型生物农药的创制

2011年度福建省科技进步奖二等奖-“龙眼褐变致腐机理及微生物保鲜关键技术的研究与应用