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夏宁邵教授博导

发布时间:2015-04-21来源:点击数:19657

夏宁邵教授 

夏宁邵  XIA Ning-Shao

教授,博士生导师

课题组组长

  话:0592-2183111

E-mailnsxia@xmu.edu.cn

实验室链接:http://nidvd.xmu.edu.cn/

 

1995年至2002年,厦门大学生命科学学院,副教授;

2002年至今,厦门大学生命科学学院,教授、博导;

2005年至今,国家传染病诊断试剂与疫苗工程技术研究中心主任;

2011年至今,厦门大学公共卫生学院,院长

1995-2002, Associate Professor, School of Life Sciences, Xiamen University

2002-present, Professor, School of Life Sciences, Xiamen University

2005-present, Director, National Institute of Diagnostics  and Vaccine Development in Infectious Diseases, Xiamen University

2011- present, Dean, School of Public Health, Xiamen University

 

研究领域(Research Area)

传染病防控的基础研究、应用基础研究、转化医学研究,诊断试剂、疫苗、抗体研发,涉及病毒性肝炎、艾滋病、流感、手足口病、结核、人乳头瘤病毒相关疾病等。

Basic, applied and translational researches for understand and control of infectious diseases; development of vaccine and diagnostics, especially for viral hepatitis, AIDS, influenza, hand-foot-mouth disease, tuberculoses and human papilloma virus-related diseases.

 

代表性论文(Selected Publications

1.     Zhu FC, Zhang J, Zhou C, Zhang XF, Huang SJ, Wang H, Yang CL, Jiang HM, Cai JP, Wang YJ, Ai X, Hu YM, Tang Q, Xian YL, Wu T, Li YM, Miao J, Ng HM, Shih JWK, Xia NS*. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomized, double-blind placebo-controlled, phase 3 trial. Lancet, 2010, 376(9744):895-902.

2.     Yuan Q, Song LW, Liu CJ, Li Z, Liu PG, Huang CH, Yan Y, Ge SX, Wang YB, Peng CY, Zhang J*, Kao JH, Chen DS, Chen PJ*, Xia NS* .Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients. Gut. 2012 Jun 14. [Epub ahead of print]

3.     Wu T, Zhu FC, Huang SJ, Zhang XF, Wang ZZ, Zhang J*, Xia NS*. Safety of hepatitis E vaccine for pregnant women: a preliminary analysis. Hepatology, 2012, 55(6): 2038

4.     Huang CH, Yuan Q, Chen PJ, Zhang YL, Chen CR, Zheng QB, Yeh SH, Yu H, Xue Y, Chen YX, Liu PG, Ge SX, Zhang J*, Xia NS*. Influence of Mutations in Hepatitis B Virus Surface Protein on Viral Antigenicity and Phenotype in Occult HBV Strains from Blood Donors. J Hepatol. 2012, 57:720-729

5.     Tang XH, Yang CY,  Gu Y, Song CL,  Zhang X, Wang YB,  Zhang J, Hew CL, Li SW*, Xia NS*, Sivaraman J *. Structural basis for the neutralization and genotype specificity of hepatitis E virus. P NATL ACAD SCI USA 2011,25(108):10266-10271

6.   Li SW, Seetharaman J., Yang CY, Gu Y, Zhang J, Du HL, Shih JWK, Hew CL, Sivaraman J, XiaNS *. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction, PLoS Pathog 2009, 5(8): e1000537.

7.     Chen YX, Qin K, Wu WL, Li GQ, Zhang J, Du HL, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen HL, and Xia NS*. Broad cross protection against H5N1 avian influenza infection using monoclonal antibodies mapping to conserved viral epitopes, Journal Infectious Disease 2009,199:49-58.

8.   Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J, Dalton HR. Hepatitis E. Lancet. 2012;379(9835):2477-88.

9.     Geng X, Huang CH, Qin Y, McCombs JE, Yuan Q, Harry BL, Palmer AE, Xia NS*, Xue D*. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Proc Natl Acad Sci U S A. 2012;109(45):18471-6.

10.  Zhang J, Shih JWK, Wu T, Li SW, Xia NS*. Development of the hepatitis E vaccine: From bench to field. Semin Liver Dis 2013; 33:79–88.

11.   Zhang J, Li SW, Wu T, Zhao Q, Ng MH, Xia NS*. Hepatitis E virus: neutralizing sites, diagnosis, and protective immunity.Rev Med Virol. 2012; 22:339-49.

 

荣誉、奖励(Honors and awards

闽江学者特聘教授,国家杰出青年科学基金获得者;国家技术发明二等奖;国家科技进步二等奖;中国专利金奖。全国传染病诊断试剂产业技术创新战略联盟理事长。

Min River Scholar; China National Funds for Distinguished Young Scientists; State Technological Invention Award; State Scientific and Technological Progress Award; WIPO-SIPO Award for Chinese Outstanding Patented Invention. Chairman, Chinese Infectious Disease Diagnostics Alliance.