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林舒勇副教授

发布时间:2015-06-19来源:点击数:7232


林舒勇,博士

副教授

Tel+86-592-2184687                                                              

E-mail: linsy@xmu.edu.cn

个人主页:https://www.researchgate.net/profile/Shu_Yong_Lin

                                                         

  

简历:

1999- 2003年,厦门大学生命科学学院,学士

2003- 2006年,香港科技大学生物化学系,博士

2006- 2009年,厦门大学生命科学学院,博士

2009- 2012年,厦门大学生命科学学院,助理教授

2012年至今,厦门大学生命科学学院,副教授

  

1999 - 2003, School of Life Sciences, Xiamen University, B.S.

2003 - 2006, Department of Biochemistry, Hong Kong University of Science and Technology, Ph.D.

2006 - 2009, School of Life Sciences, Xiamen University, Ph.D.

2009 - 2012, School of Life Sciences, Xiamen University, Assistant Professor

2012 - now, School of Life Sciences, Xiamen University, Associate Professor

  

研究领域Research Area)

营养感应关键蛋白质和信号通路在生理和病理状态下的调控方式和作用机制,具体包括AIDAAxin1p53等代谢调控枢纽蛋白以及GSK3-TIP60-ULK营养感应信号通路在营养感应、糖脂代谢以及肥胖、糖尿病和肿瘤等代谢性疾病发生发展过程中的调控和功能实现机制。

The regulatory mechanisms and functions of the hub proteins of metabolic regulation such as AIDA, Axin1 and p53, and nutrient sensing pathways such as GSK3-TIP60-ULK axis under physiological or pathophysiological processes, including nutrient sensing, carbohydrate and lipid metabolism and the development of metabolic disorders such as obesity, diabetes and cancer.

  

代表性论文(Selected Publications) * Corresponding author  # co-first author

1. Luo H(#), Jiang M(#), Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY(*), Lin SC(*). AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metabolism 2018 Apr 3;27: 843-853.e6.

2. Sun Y(#), Li TY(#), Song L(#), Zhang C, Li J, Lin ZZ, Lin SC, Lin SY(*). Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology 2017 doi: 10.1002/hep.29759.

3. Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC(*). ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Molecular Cell 2016 62: 359-370.

4. Zheng LS(#), Liu YT(#), Chen L, Wang Y, Rui YN, Huang HZ, Lin SY, Wang J, Wang ZX, Lin SC, Wu JW(*). Structure and mechanism of the unique C2 domain of Aida. FEBS J. 2014 281: 4622-4632. 

5. Li TY, Lin SY, Lin SC(*). Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda) 2013 28: 423-431.

6. Ruan K(#), Ye F(#), Li C(#), Liou YC, Lin SC, Lin SY(*). PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation. PLoS One 2012 7: e49184.

7. Lin SY(#), Li TY(#), Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC(*). Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy 2012 8: 1385-1386.

8. Lin SY(#), Li TY(#), Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC(*). GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy. Science 2012 336: 477-481.

9. Lin S(#), Han Y(#), Shi Y, Rong H, Zheng S, Jin S, Lin SY, Lin SC, Li Y(*). Revealing a steroid receptor ligand as a unique PPAR gamma agonist. Cell Research 2012 22: 746-756.

10. Cheng Y, Wang J, Shao J, Chen Q, Mo F, Ma L, Han X, Zhang J, Chen C, Zhang C, Lin S, Yu J, Zheng S, Lin SC, Lin B(*). Identification of Novel SNPs by Next-Generation Sequencing of the Genomic Region Containing the APC Gene in Colorectal Cancer Patients in China. OMICS: A Journal of Integrative Biology 2010 14: 315-325.

11. Li Q(#), Lin S(#), Wang X(#), Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC(*). Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology 2009 11: 1128-1134.

12. Luo JM, Dai CF, Lin SY, Huang PQ(*). Asymmetric Syntheses and Wnt Signal Inhibitory Activity of Melleumin A and Four Analogues of Melleumins A and B. Chemistry-An Asian Journal 2009 4: 328-335.  

13. Lin S(#), Wang J, Ye Z, Ip NY, Lin SC(*). CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Letters 2008 582: 1197-1202.

14. Rui Y(#), Xu Z(#), Xiong B(#), Cao Y(#), Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A(*), Lin SC(*). A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental Cell 2007 13: 268-282.

15. Luo W, Zou H, Jin L, Lin S, Li Q, Ye Z, Rui H, Lin SC(*). Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. Journal of Biological Chemistry 2005 280: 5054-5060.

16. Rui Y(#), Xu Z(#), Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC(*). Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO Journal 2004 23: 4583-4594.


荣誉、奖励及参加学术团体的情况Honors and award, Professional service

福建省青年拔尖创新人才

Youth Top-notch Talent in Fujian province