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徐庆妍副教授

发布时间:2015-02-20来源:点击数:4845

徐庆妍副教授徐庆妍  XU Qingyan, Ph.D.

副教授硕士生导师

  :+86-592-2180328

E-mail: xuqingyan@yahoo.com

 

1992,华西医科大学药学院(今四川大学华西药学院),学士学位;

1995,华西医科大学药学院(今四川大学华西药学院)天然药化专业,硕士学位;

2004,厦门大学,理学博士学位;

2006年至2007,法国斯特拉斯堡市路易-巴斯德大学药学院,博士后;

1995年至今,厦门大学生命科学学院,助教、讲师、副教授。

 

1992, B. Sc.  West China University of Medical Science

1995, M. Sc.  West China University of Medical Science

2004, Ph. D.  Xiamen University

2006-2007, Postdoctoral Fellow, Louis-Pasteur University, Strasbourg, France

1995-present, Assistant Professor, Associate Professor, School of Life Science, Xiamen University

 

研究领域(Research Area

微生物药物学。从事与微生物活性代谢产物相关的研究。除抗菌、抗肿瘤活性外,目前主要从事抑制肿瘤坏死因子TNF-α)活性的小分子化合物的研究,希望可以找到阻断TNF-α导致细胞坏死的信号通路的药物。

Microbial Pharmacology. The main research area lies in Microbial Pharmacology. More than antibacterial and antitumor activities, we focus on the research of compounds with anti-TNF-α activity. We hope to find inhibitors that block the necrosis signaling pathway of TNF-α from microorganisms.

 

代表性论文(Selected Publications

1.     Liu J L., Hu Z Y., Huang Y J., Zheng Z H, Xu Q Y*.  Aspochalasin U, a moderate TNF-α inhibitor from Aspergillus sp[J]. Journal of Antibiotics. 2012, 65 : 49-52.

2.     Liu J L, Hu Z Y, Xu Q Y*. 3 '-(3-Hydroxyphenyl)-4-methylspiro benzo e 1,4 diazepine-3,2 '-oxirane -2,5(1H, 4H)-dione[J]. Acta Crystallographica Section E - Structure Reports Online, 2011, 67: O1670 - U1532. 

3.     Zimmermann M, Atmanene C, Xu Q Y, Fouillen L, Van Dorsselaer A, Bonnet D, Marsol C, Hibert M, Sanglier-Cianferani S, Pigault C, McNamara LK, Watterson DM, Haiech J*, Kilhoffer MC. Homodimerization of the Death-Associated Protein Kinase Catalytic Domain: Development of a New Small Molecule Fluorescent Reporter[J]. PLoS ONE, 2010, 5(11). E14120.

4.     Zhan Y Y, Du X P, Chen H Z, Liu J J, Zhao B X, Huang D H, Li G D, Xu Q Y, Zhang M Q, Weimer B C, Chen D, Cheng Z, Zhang L R, Li Q X, Li S W, Zheng Z H, Song S Y, Huang Y J, Ye Z Y, Su W J, Lin S C, Shen Y M, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77 [J]. Nature Chemical Biology, 2008, 4(9):548-556.

5.     Xu Z, Xu Q Y, Zheng Z H, Huang Y J*. Kribbella amoyensis sp. nov., isolated from the rhizosphere soil of a pharmaceutical plant, Typhonium giganteum Engl [J]. International Journal of Systematic and Evolutionary Microbiology, 2011. PMID: 21705443.