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刘润忠教授

发布时间:2015-11-23来源:点击数:1218

 

刘润忠 Ph.D.

教授,硕士生导师

课题组:转录调控与疾病

电话:+86- 592-2181321

E-mail:liurz@xmu.edu.cn

  

1982年,江西大学,理学学士;

1990年,中国科学院武汉病毒研究所理学硕士;

1991年,中国科学院武汉病毒研究所助理研究员;

1996年,中国科学院武汉病毒研究所副研究员;

1997至2000年,美国Cornell University访问学者;

2000至2001年,美国 University of Arkanses for Medical Sciences 访问学者;

2002年,厦门大学生命科学学院副教授;

2006年,厦门大学生命科学学院理学博士

2004至2005年,美国 The Burnham Institute 访问学者。

2016年-至今,厦门大学生命科学学院教授

B.S. Jiangxi University (1982)

M.S. Wuhan Institute of Virology, The Chinese Academy of Sciences(1990)

Assistant researcher in Wuhan Institute of Virology, The Chinese Academy Sciences (1991)

Associate researcher in Wuhan Institute of Virology, The Chinese Academy Sciences(1996)

Sep, 1997-Mar,2000, Cornell University as a visiting scholar.

Apr, 2000-May, 2001, University of Arkanses Medical Sciences as a visiting scholar.

Associate professor in School of Life Sicences ,Xiamen University(2002)

Ph.D of Biochemistry and Molecular Biology. School of Life Sicences ,Xiamen University(2006)

Aug, 2004-July, 2005, The Burnham Institute (San Diego)

 

研究领域(Research Area

主要从事神经退行性疾病如Alzheimer disease(AD)病理机制以及正性转录延伸因子(P-TEFb)在神经干细胞中的转录调节作用机理研究。特别是HIV-1 Tat蛋白对大脑神经元中P-TEFb的调节对神经退行性疾病的影响。

Our research focuses on understanding the molecular events that underlie the pathogenesis of neurodegenative diseases such as Alzheimer’s disease (AD) and the mechanism of positive transcriptional elongation factor b(P-TEFb) regulation transcription in neural stem cells. Especially on the mechanism of the HIV-1 Tat protein regulation P-TEFb of neurons for neurodegenative diseases.

  

 

代表论文(Selected Publications

1.Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, Rao M, Yang H, Zhou K, Wang Y, Chen Y, Chen M, Zhuang S, Chen LF,Liu R, Chen R. Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.Nucleic Acids Res. 2016 Aug 19;44(14):6853-67. doi: 10.1093/nar/gkw571. Epub 2016 Jun 28. IF=9.202

2. Hu X, Lu X,Liu R, Ai N, Cao Z, Li Y, Liu J, Yu B, Liu K, Wang H, Zhou C, Wang Y, Han A, Ding F, Chen R. Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression. J Biol Chem. 201415;289(33):23154-67. doi: 10.1074/jbc.M114.570812. Epub 2014 Jun 17. IF=4.573

3.Lin D,Wang Q, Ran H, Liu K, Wang Y, Wang J, Liu Y, Chen R, Sun Y,Liu R, Ding F.Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome.Endocrinology. 2014 Jul;155(7):2355-62. doi: 10.1210/en.2013-2083. Epub 2014 Apr 15. IF=4.503  

4. Huiping Wang,Xinxing Zhu,Ying Zhu,Jiangfang Liu,Xiangming Hu,Yu Wang,Sijia Peng,Yanheng Chen,Ruichuan Chen,Feng Ding,andRunzhong Liu. Protein Kinase D3 Is Essential for Prostratin-Activated Transcription of Integrated HIV-1 Provirus Promoter via NF-KB Signaling Pathway.Biomed Res Int. Volume 2014; 1-11 . IF=1.579

5. Wei Wang, Xiao Yao, Yan Huang, Xiangming Hu,Runzhong Liu, Dongming Hou, Ruichuan Chen and Gang Wang. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. Transcription.2013; 4:1, 39–51.

6.Runzhong Liu, Haibo Hou, Xuelian Yi, Shanwen Wu, Huan Zeng. Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein. Neural Regeneration Research 2013;8(11):991-999, doi: 10.3969/j.issn.1673-5374.2013.11.004. IF=0.203

7.Wang H, Zhou N, Ding F, Li Z, Chen R, Han A,Liu R. An efficient approach for site-directed mutagenesis using central overlapping primers. Anal Biochem. 2011 Nov15;418(2):304-6.IF=2.996

8.Ai N, Hu X, Ding F, Yu B, Wang H, Lu X, Zhang K, Li Y, Han A, Lin W,Liu R, Chen R. Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. Nucleic Acids Res. 2011 39(22):9592-604 IF=8.026

9.Nan Zhou, Shanwen Wu, Yu Wang, Xinzhu Tong, Ruichuan Chen and Runzhong Liu. An improved protocol for efficient one-step PCR site-directed mutagenesis with partial-overlapping primers. ITME 2011 - Proceedings: 2011 IEEE International Symposium on IT in Medicine and Education, v 2, p 616-619, 2011, December 9-11,2011, Guangzhou, China. EI number: 20120714768004

10.Ying Zhu, Feng Ding, Aweya Jude Juventus, Nan Zhou1, Huan Zeng, Shanwen Wu, Yu Wang, Xinzhu Tong, Ruichuan Chen andRunzhong Liu. PKD3 is required for prostratin-activated HIV-1 transcription. 2011,ITME 2011 - Proceedings: 2011 IEEE International Symposium on IT in Medicine and Education. v 2, p 606-610, December 9-11,2011, Guangzhou, China.EI number: 20120714767995

11.Gao YY, Zhang DF, Li H,Liu R, Zhuang ZH, Li QF, Wang SY, Peng XX. Proteomic approach for caudal trauma-induced acute phase proteins reveals that creatine kinase is a key acute phase protein in amphioxus humoral fluid.J Proteome Res. 2007 Nov;6(11):4321-9. IF=5.68

12.Zhang H,Liu R, Wang R, Hong S, Xu H, Zhang YW. Presenilins regulate the cellular level of the tumor suppressor PTEN.Neurobiol Aging. 2008 May;29(5):653-60. IF=5.959

13.Wang R, Zhang YW, Sun P,Liu R, Zhang X, Zhang X, Xia K, Xia J, Xu H, Zhang Z.  Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.Mol Cell Biol. 2006 Feb;26(4):1347-54. IF=6.773

14.Wang R, Zhang YW, Zhang X,Liu R, Zhang X, Hong S, Xia K, Xia J, Zhang Z, Xu H. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 2006 Jun;20(8):1275-7. Epub 2006 Apr 27. IF=6.721

 

主持和参与的科研基金项目

1.国家自然科学基金面上项目,30572077,早老素(PS1)在囊泡合成及运转中的调节功能研究,2006/01-2008/12, 25万元,已结题,主持

2.国家自然科学基金面上项目,81171192,突变型早老素(PS1Del9)活性多肽调节PTEN对老年痴呆病(AD)tau蛋白磷酸化的影响,2011/01-2014/12, 56万元,已结题,主持

3.国家自然科学基金重点项目,30930046,P-TEFb 重活化调控机制及其对细胞周期的影响,2010/01-

  2013/12, 165万元,已结题,参与,排名第二

4.国家重大基础研究计划(973计划),2013CB917802,基因延伸转录及终止因子对APA的作用和机

  制, 241万元,已结题,参加,排名第三

5.福建省自然科学基金面上项目,2013J01356,早老素蛋白(PS1)相互作用蛋白调节功能研

  究,2013/01-2015/12, 5万元,已结题,主持