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肖昌春教授博导

发布时间:2015-04-23来源:点击数:3355

  

肖昌春  XIAO Changchun, Ph.D

教授,博士生导师

话:0592-288 0351

E-mailcxiao@xmu.edu.cn


1995年,清华大学, 学士学位;

2002年,美国耶鲁大学,博士学位;

2002-2003年,美国耶鲁大学博士后;

2004-2008年,美国哈佛大学医学院免疫疾病研究所博士后

2008年,美国Scripps研究所助理教授

2014年,美国Scripps研究所副教授;

2015年,厦门大学生命科学学院教授, 入选福建省百人计划。

1995, BSc., Tsinghua University, China;

2002, Ph.D.  Yale University, USA;

2002-2003, Postdoctoral Fellow, Yale University, USA;

2004-2008, Postdoctoral Fellow, Harvard Medical School Immune Disease Institute, USA;

2008, Assistant Professor, Department of Immunology and Microbial Science, The Scripps ResearchInstitute, USA;

2014, Associate Professor, Department of Immunology and Microbial Science, The Scripps ResearchInstitute, USA;  

2015,Professor,  School of Life Sciences, Xiamen University, Xiamen, China.

 

研究领域(Research Area

本实验室主要研究非编码RNA和RNA结合蛋白在免疫系统中的功能与作用机理。我们采取表达谱分析和体外体内功能筛选等方法,寻找在免疫系统中发挥重要作用的非编码RNA和RNA结合蛋白, 然后构建基因敲除以及转基因小鼠,研究这些基因在生理和病理情况下的免疫学功能。 我们结合转录组学,翻译组学,以及其它的分子,生化,和细胞学分析方法,试图在机体,细胞,和分子三个水平上理解免疫系统在健康与疾病状况下发挥作用的分子与细胞机理。我们研究方向包括:淋巴细胞的发育与分化,免疫耐受与自身免疫病,抗体反应,抗病毒反应,抗肿瘤反应,淋巴癌和白血病。

The primary focus of our laboratory is to study the function and mechanism of non-coding RNAs and RNA-binding proteins in the immune system. We employ expression profiling and in vitro/in vivo functional screens to identify functionally important non-coding RNAs and RNA-binding proteins. We will then generate mutant mice with loss- and gain-of function mutations for these genes and use these mice to study their physiological and pathological functions. We strive to elucidate the cellular and molecular mechanisms underlying a functional immune system under health and disease conditions at the organismal, cellular, and molecular levels. To achieve this goal, we combine multiple experimental approaches including mouse genetics, transcriptome and translatome analysis, molecular biology, cell biology, and biochemistry, and often elicit help from collaborators around the world. Specifically, we are interested in:

1. The development, differentiation, and function of B and T lymphocytes;

2. Immune tolerance and autoimmune diseases;

3. Antibody response and its roles in chronic virus infection;

4. Cancer-immune system interactions and cancer immunotherapy;

5. Lymphoma and leukemia.


 

代表论文(Selected Publications  

1.Jin HY, LaiM, Shephard J,XiaoC(2016)Concurrent PI3K and NF-kB activation drives B cell lymphomagenesis.Leukemia.advance online publication 26 August 2016; doi: 10.1038/leu.2016.204

2.Liu WH, Kang SG, HuangZ, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, ZhengY, Lu LF, Xiao N, Fu G,Xiao C(2016) A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.J ExpMed213(9): 1910-1919.

3.Ma H, Pan JS, Jin LX, Wu J, Ren YD, Chen P,Xiao C#, Han J# (2016), MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis.Cancer Letters376(2):293-302. (#共同通讯作者)

4.LaiM, Gonzalez-Martin A,CooperAB, OdaH, Jin HY, Shepherd J, He H, ZhuJ NemazeeD,XiaoC (2016) Regulation of B Cell Development and Tolerance by Different Members of the miR-17~92 Family MicroRNAs.Nature Communications,2016 Aug 2;7:12207. doi: 10.1038/ncomms12207

5.IchiyamaK, Gonzalez-MartinA, Kim BS, JinHY, Sabouri-Ghomi M, Xu S, Zheng P,XiaoC#, Chen Dong (2016) The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicityby negatively regulating transcription factor Foxo1 expression.Immunity44, 1284–1298.(#共同通讯作者)

6.Gonzalez-MartinA, AdamsBD, LaiM, ShepherdJ, Salvador-BernaldezM, SalvadorJM, LuJ, NemazeeD,XiaoC(2016) The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.Nature Immunology17:433-40.

7.Jin HY, Gonzalez-Martin A, Miletic AV, Lai M, Knight S, Sabouri-Ghomi M, Head SR, Macauley MS, Rickert RC,Xiao C (2015) Transfection of microRNA Mimics Should Be Used with Caution.Front Genet.6:340.

8.Jin HY,Xiao C(2015) MicroRNA Mechanisms of Action: What have We Learned from Mice?Front Genet.6:328.

9.Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K,Xiao C(2013) MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.The EMBO J., 32:2377-91.

10.Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MBA, Qi H, Teijaro JR,Xiao C(2013) MiR-17~92 family microRNAs are critical regulators of T follicular helper cell differentiation.Nature Immunology14:849-57.

11.Xiao Cand Rajewsky K. (2009) MicroRNA Control in the Immune System: Basic Principles.Cell136: 26-36.

12.Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K. (2008) Lymphoproliferative disease and autoimmunity in mice with elevated miR-17-92 expression in lymphocytes.Nature Immunology 9:405-14.

13.Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. (2007) MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell131: 146-159.

14.Thai TH, Calado DP, Casola S, Ansel KM,Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. (2007) Regulation of the germinal center response by microRNA-155.Science316: 604-608.

15.Monticelli S*, Ansel KM*,Xiao C*, Socci ND*, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, RaoA, Kosik KS. (2005) MicroRNA profiling of the murine hematopoietic system.Genome Biology6(8): R71. (*共同第一作者)

16.Shim JH*,Xiao C*, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. (2006) CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.Journal of Cell Biology 172: 1045-1056. (*共同第一作者)

17.Shim JH,Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Genes & Development19: 2668-2681.

18.Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.Genes & Development 17: 2933-2949.